Aussie-Sino Studies

2017, (3) P80-P83

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The Correlation of Virus Infection and Chronic Obstructive Pulmonary Disease and Its Influence on Airway Inflammation

Pan Zebin & Ji Xiaoping & Guo Xi

摘要(Abstract):

Objective: To explore the correlation between virus infection and chronic obstructive pulmonary disease and its influence on airway inflammation. Methods: To select 95 cases of chronic obstructive pulmonary disease in patients with acute aggravating period (severe COPD group ), 52 patients with stable COPD (stable COPD group) and 28 cases of healthy people (healthy group) as the research object in our hospital from December 2013 to March 2017,Virus specific IgM antibody and IgG level condition of respiratory syncytial virus(RSV),Herpes simplex virus type 1(HSV-1),adenovirus(ADV),cytomegalovirus(CMV)were detected by ELISA.At the same time, according to the specific antibody of virus IgM detection results and clinical manifestations.95patients with acute exacerbation were divided into A group of 32 cases and B group 63 cases.Sputum interleukin 6(IL-6)and tumor necrosis faclor alpha(TNF-α) level were measured and analysis of two groups of patients before and after treatment, and the results were statistically analyzed.Results: The total virus positive rate of serve COPD group (88.42%)and stable COPD group (71.15%) was respectively significantly higher than that of the health group(20.59%,χ2=15.969,P<0.01).The IgM positive rate of serve COPD group(33.68%)was higher than that of the health group(5.88%).The IgG positive rate of two groups was respectively higher than that of health group(P<0.0 1).Sputum IL-6and TNF-α decreased significantly after treatment than before treatment(P<0.05).Compared with group B, group A of interleukin 8 level decreased more significantly (P < 0.01); Two groups of tumor necrosis factor alpha diff has no statistical significance (P > 0.05). Conclusions: Viral infection is one of the important risk factors of acute exacerbation of COPD, particularly with the effect of respiratory syncytial virus the most, usually cause airway inflammation is aggravating, need to strengthen the prevention and treatment of virus infection in clinical.

关键词(KeyWords): Virus, infection, chronic obstructive pulmonary disease, airway inflammation, correlation

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作者(Author): Pan Zebin & Ji Xiaoping & Guo Xi

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