Aussie-Sino Studies

2017, (2)

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Comparison of the Efficacy of Continuous High Volume Hemofiltration and Conventional Volume Hemofiltration in the Treatment of Sepsis Patients with MODS

Song Yongxin, Yan Zhixing, Yuan Jie, Lu ZhaoXin, An PengPeng, Wang Jun,Guan QingHua, Xu Xiaowen, Su Yimei, Wang Feng, Ding Minggang

摘要(Abstract):

Objective: To explore the therapeutic effect of continuous high volume hemofiltration program in sepsis patients with multiple organ dysfunction syndrome (MODS). Method: During the period from 2013 March to 2015 December, A total of 100 cases of sepsis patients with MODS caused by various factors from the intensive care units of a hospital were selected and assigned to receive CHVHF(n=53) and continuous volume hemofiltration (CVHF, n=47). The changes of vital signs, hemodynamic parameters, MODS score, acute physiology & chronic health evaluation Ⅱ (APACHE Ⅱ) score, procalcitonin (PCT), arterial blood lactate, liver & kidney function parameters were observed before and after treatment. Result: After CHVHF treatment, body temperature and heart rate of patients were improved to a certain extent(t=7.059,P<0.01;t=12.014,P<0.01); the hemodynamic parameters in 48, 72 h appear to improved, cardiac index(CI), mean arterial pressure(MAP), systemic vascular resistance index(SVRI), stroke volume index(SVI) tend to be stable, MODS score and APACHE II score were significantly decreased, (F=30.026, P<0.01; F=87.950, P<0.01; F=367.944, P<0.01; F=217.257, P<0.01). There is a significant changes compare with treatment before, the difference was statistically significant (both P<0.05); PCT and arterial blood lactic acid ,liver and kidney function indexes were gradually returned to normal at 24, 48 and 72 h post-treatment (F= 21.210, P<0.01; F=76.410, P<0.01; F=86.060, P<0.01; F=199.800, P<0.01; F=120.900, P<0.01; F=162.100, P<0.01). Conclusion: CHVHF may stabilize vital signs and improve hemodynamic, tissue perfusion and organ function in sepsis patients with MODS.

关键词(KeyWords): sepsis, Continuous blood filtration, Multiple organ dysfunction syndrome

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作者(Author): Song Yongxin, Yan Zhixing, Yuan Jie, Lu ZhaoXin, An PengPeng, Wang Jun,Guan QingHua, Xu Xiaowen, Su Yimei, Wang Feng, Ding Minggang

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